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Mercaptan Known effects:
Alteration in collagen metabolism
Pooling of Type 1 procollagens
Suppression of DNA synthesis
Reduction in Proline Transport (an amino acid discovered in 1910. it is a major constituent of collagen)
Depresses hepatic cytochrome oxidase hepatic splenic and erythrocyte oxidase activity
Hepatic Coma
Inhibits Na+, K+ ATPase activity
Decrease in body weight
Hydrogen Sulphide known effects:
CNS is major target organ
Reduction in respiratory rate
Alters neurotransmitters
Blood glucose elevated in pregnancy
Behavioral and Structural abnormalities
Developing neurons at risk of severe deficit
Increase in hippocampal theta activity
Cumulative changes in hippocampal function
Rapid suppression of breathing
Seratonin levels increased
Norepinephrine reduced
K+- chanel-mediated hyperpolarisation of neurons
Potentiation of other inhibitory mechanisms
Anoxia
Clinical impairment of cognition
Changes in pulmonary function
Olefactory paralysis
neurophysiological abnormalities
Visual recall is impaired
These compounds are all toxic to mammalian enzymes if present in large enough quantities.