It is well known that mercury accumulates in the heart. [1],[2] Mercury Vapour from amalgam fillings is transported around the body by the blood. It readily crosses the placenta, breast milk and the blood brain barrier.[3],[4],[5],[6] Massive levels of mercury will be found in the heart, brain and foetus. [7],[8].
Once the mercury is in the cell, it is transformed into inorganic mercury which is very difficult to move across the cell membrane and back out of the cell. It is in this way that is does the most damage. It also means that it stays in the tissues for a very long time.[9]
Heart Disease is strongly linked to mercury exposure.
Perhaps the PTOs consider this an insignificant side effect? Mercury will cause heart attacks. It can affect the regulation of the heartbeat. Mercury can cause an increase in blood pressure. It can cause palpitations. It can cause tachycardia. Mercury can be the cause of arrhythmias. Mercury will seriously affect the lining of the heart, (endocardium) and the lining of the arteries (endothelial cells). Mercury is profoundly cardiotoxic. [10],[11],[12],[13],[14]
“… amalgam-bearing subjects had significantly higher blood pressure, lower heart rate, lower hemoglobin, and lower hematocrit. Hemoglobin, hematocrit, and red blood cells were significantly lower when correlated to increased levels of urine mercury. The amalgam subjects had a greater incidence of chest pains, tachycardia, anemia, fatigue, tiring easily, and being tired in the morning.” [15]
“… Hg exposure induced baroreflex hyposensitivity and produced a drastic alteration of the levels of copper and zinc in brain and kidney.” [16]
“…chronic mercury exposure affects cardiovascular function by interfering with the baroreflex mechanisms and/or the reactivity to catecholamines.” [17]
The Baroreflex controls blood pressure. Rarely does the medical research include mercury as a potential cause of baroreflex failure.
The arterial baroreflex buffers acute fluctuations in blood pressure that occur during posture, stress, or other maneuvers. When blood pressure rises, vascular distension is transduced into nervous electrical activity, triggering reflex parasympathetic activation and sympathetic inhibition. Heart rate is slowed and vascular resistance is decreased, buffering the increase in blood pressure. Conversely, baroreceptor activity decreases when blood pressure falls, producing a reflex-mediated increase in heart rate and peripheral resistance. Baroreceptor activity is reset during sustained increases in blood pressure so that in patients with essential hypertension, baroreceptor responsiveness is maintained. However, the resetting of the baroreflex plays at least a permissive role in perpetuation of hypertension. Guyton argued that the baroreflex is responsible for the minute-to-minute regulation of blood pressure, but that the long-term blood pressure regulation is related to volume mechanisms adjusted by the kidneys. However, faulty baroreflexes can occasionally influence long-term blood pressure regulation. An example is the condition of baroreflex failure.
Karsten Heusser, Jens Tank, Friedrich C. Luft and Jens Jordan Hypertension. 2005;45:834–839
Catecholamines regulate physiological changes that prepare the body for physical activity e.g., the fight-or-flight response. Some typical effects are increases in heart rate, blood pressure, blood glucose levels, and a general reaction of the sympathetic nervous system.
The condition known as Idiopathic Dilated Cardiomyopathy (IDCM), means simply a heart attack that has no known cause. It is commonly seen in younger fit people such as healthy athletes, who suddenly drop dead. Mercury has been positively associated with IDCM as a direct cause! [18],[19],[20] Levels of mercury in the heart of people who die from IDCM are on average 22,000 times higher than in other tissues and likewise dramatically higher than the rest of the population.
Mercury is stored in heart tissue and has a toxic and damaging effect on both heart muscle and heart valves. [21],[22],[23],[104],[24],[25],[26]
Mercury poisoning may also cause chest pain or angina, especially in individuals under age 45. [27] Methyl Mercury can inhibit the activity of paraoxonase, a family of enzymes which normally protect the heart muscle. [28]
Selenium is massively important for the functioning of a large number of enzymatic processes in the body. It is regarded as an essential trace element. It is an important anti-inflammatory and is important for the reduction of oxidative stress.
Mercury binds strongly to selenium, and effectively removes it from having any positive function in the body.
Supplementation with selenium is thus part of the detox protocol for mercury, when you get your amalgams replaced. Due to mercury’s ability to bind selenium, there will be less available for functioning of heart muscles. Many studies have shown a depletion of selenium and an increase in cardiovascular disease. Selenium is essential for healthy heart function and just about every process in your body from thyroid function to sperm production. [29],[30],[31],[32],[33],[34]
Other studies also correlate mercury exposure with increased risk of hypertension, myocardial infarction, coronary dysfunction, and atherosclerosis. [35],[36],[37],[38] Mercury exposure is associated with the progression of atherosclerosis and an increased risk of developing cardiovascular disease.[39] In another study patients were followed for approximately 13 years and found an association between the concentration of mercury in the hair, and the risk of developing cardiovascular events or dying from cardiovascular disease.[40]
Studies on rats have shown that after only 30 days of exposure to mercury, the cells lining the blood vessels and the heart have already started a downward spiral of disease, even though there was no change in arterial blood preasure at this stage. [41],[42]
Taken together, these data show that chronic low doses of mercury have an important and deleterious effect on vascular function. The degree of severity of mercury exposure is comparable to traditional cardiovascular risk factors, such as high blood pressure, diabetes or high cholesterol.
“Therefore, mercury could be considered an important risk factor for cardiovascular disease that could play a role in the development of cardiovascular events. The association between mercury exposure and an increased risk of developing cardiovascular and neurological diseases is apparent. Thus, continuous exposure to mercury can be dangerous, and current reference values, once considered to be without risk, should be re-evaluated and reduced.” [43],[44],[45],[46]
One might well ask why this is NOT common knowledge amongst cardiologists. I have spoken to many who still believe that the mercury is locked into amalgam and has nothing to do with heart disease. It is incredible that such intelligent people are not interested in one of the major causes & prefer to believe the dental propaganda instead of reading the research. (It reminds me of a gastroenterologist I once knew, who believed that diet had nothing to do with gut health. He also believed that mercury from amalgam could not possibly affect gut bacteria and was irrelevant.)
I have my own cognitive dissonance around this. I cannot understand why the medical profession as a whole and their specialties, have been so slack about calling the dental profession to task about poisoning us all.
Heart disease is the biggest killer in our society, and they don’t want to know about one of the main predisposing factors. Are we condemned to only treating symptoms? Surely if you are a specialist cardiologist or neurologist, you would have a responsibility to understand the causes of the diseases you claim to treat. Does anybody want to look at a cause? It’s doubtful. I’ve met several cardiologists who are happy to take statins themselves, while keeping a mouthful of amalgam fillings in their own heads! ‘Sheeple’ come in all shapes and sizes.
The dental profession must also be held accountable for the misconceptions and lies, which have cost so many, so dearly. The dental profession is responsible for polluting both people and the environment with mercury. The PTOs and universities are responsible for promoting this behaviour.
Cholesterol
Mercury Increases Cholesterol
Currently, the medical profession is dealing with a great controversy about the levels of good and bad cholesterol and their effects on heart and arterial disease. Before Statins came onto the market, the average ‘normal’ cholesterol level was 4.0-5.5 mmol/L. After cholesterol lowering drugs came on the market, the new maximum for cholesterol became 3.5. mol/L.
The decision to lower the ‘normal’ cholesterol level was not based on science. It turns out that 8 of the 9 people who were entrusted to make this decision, had direct financial ties to the manufacturers. Simply lowering the threshold, meant that millions more were eligible to take the drug. Suddenly everyone needed the new miracle drug to lower their cholesterol and thus save their heart attack and their lives. Every doctor believed the studies that were done by the manufacturer. The original research material has never been released to either the public or other research scientist.
This of course represented an increase in market sales. Statins are the most prescribed cholesterol lowering drug worldwide. Lipitor by Pfizer, is the most profitable drug in the history of medicine, and the total sales are expected to reach $1 trillion by 2020 [47]
“Doctors are now seeing the effects of a phenomenon called ‘diagnosis creep’, whereby simply changing the definition of a disease or lowering the threshold of a surrogate marker turns healthy people into patients and leads to overdiagnosis and unnecessary treatments.”
Dr Demasi. Statin wars: have we been misled about the evidence? A narrative review. BJSM Online First, published on January 21, 2018 as 10.1136/bjsports-2017-098497
It is now time for a rethink!
“Higher levels of lead and other heavy metals detected in the blood was associated with increased levels of lower density lipoprotein (LDL — bad cholesterol) and total cholesterol”. “The rise in cholesterol seen with increasing heavy metal levels in the blood might have cardiovascular consequences in people exposed to heavy metals…”
The American Heart Association information released on 5 November 2018
“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of The New England Journal of Medicine.” 1
Editor in Chief of The New England Journal of Medicine, Dr Marcia Angell
Compared with those who had the lowest levels of a metal, those with the highest:
– had 56% greater odds of having higher total cholesterol if they have the highest level of lead;
– were 73% more likely to have higher total cholesterol if they had the highest levels of mercury in their blood;
– had 4% higher risk of elevated total cholesterol if their cadmium levels were in the highest levels; and
– were 22% more likely to have higher bad cholesterol if they were in the highest lead levels. [48]
If you have mercury in your body, you will have elevated levels of cholesterol in your body. There is a reason for this. Mercury is fat soluble. It will be stored in cholesterol as a way of the body protecting more sensitive areas, like the heart or the brain.
November 2018 is also the time when the NSW government has announced that the water supply to Sydney and most of NSW has unacceptable lead levels. It will be interesting to see if there is an increase prescription rate for statins. Buy a Reverse Osmosis Filter for your drinking water, which will remove heavy metals like lead and arsenic and also fluoride. (fluoride leaches lead off the old solder joints and we are forced to drink it as part of the government’s forced medication campaign.)
Mercury’s ability to increase the cholesterol levels in the body makes it a risk factor for heart attacks and other cardiac diseases. [49] Mercury levels are predictors of the levels of oxidized low-density lipoprotein (LDL) – the supposedly ‘dangerous’ cholesterol. 123,[50] Oxidized LDL particles are frequently found in atherosclerotic lesions and have been associated with the development of atherosclerotic disease124,[51] and acute coronary insufficiency.[52] Another mechanism by which mercury exerts toxic effects on the cardiovascular system, is through the inactivation of “paraoxonase”, [53] an enzyme that slows the LDL oxidation process and that has an important anti-atherosclerotic action. [54]
“Cholesterol elevations are the result of efforts of our liver to assist in detoxification of dental mercury.” [55]
“…an investigation was started to determine the difference between “good” and “bad” cholesterol. Chemically, there is no difference. The HDL, or high density cholesterol is just packed together tighter. In point of fact, what is called bad cholesterol, is what makes hormones and serotonin. The Toxic Element Research Foundation
As it turns out, cholesterol is one of our primary defenders, not offenders.
Among its attributes is the fact that it provides great protection against most anaerobic (the really bad ones) bacteria. [56] Cholesterol inactivates or inhibits bacterial “hemolytic activity” (boring holes into red blood cells, such that the contents leak out, producing death of the cell). [57]
“…Red blood cells are 7 microns in diameter, yet they slither through capillaries that are only 5 microns in diameter. How can they do that? They fold and bend upon themselves – provided they have 23% cholesterol in their outer membranes. Lower than that, and the red blood cells lose their flexibility, becoming lodged in the capillaries, creating little mini-strokes.” TERF
Serotonin levels are directly controlled by cholesterol levels. Your happiness is thus controlled by the level of cholesterol in your body. [58],[59] Violent behavior was reported in low cholesterol homicidal offenders. [60]
“Interventions to reduce cholesterol concentrations on a large scale could lead to a population shift to a more violent pattern of behavior, which would result not in death, but in more aggression at work and at home, more abuse of children, and partners, and generally more unhappiness.” [61]
This was written in 1979. We have moved from love and peace ‘hippydom’ in the seventies to more dispassionate times now, where road rage and murderous wars are the norm that most people just accept. ‘Severe depression’ is medically defined as “life threatening, wherein the patient is contemplating suicide.” [62] The lower the cholesterol, the more severe the depression.
A little historical perspective:
1980
Lowering cholesterol leads to a reduction in cognitive function in people taking statin drugs. [63]
1984
In studies where cholesterol was rapidly reduced there was a marked increase in the rate of heart attacks. One group of Japanese men over the age of 60 were followed into old age. Those who had lost weight rapidly were far more likely to have dementia as an outcome. This is particularly important for those people who have very little body fat to start with. Mercury is fat soluble. When there is little body fat, the mercury only has a few places to go to find these fats. Heart, Kidneys and Brain! The group taking cholesterol-lowering drugs, had an increase in deaths from cancer, stroke, violence and suicide. [64]
1990
In “mortality” studies, or death by all causes, a W.H.O. study of 6,582 patients in cholesterol lowering drug trials, found a 44% increase in overall mortality in those patients taking statin (cholesterol lowering) drugs. [65]
1991
“In a review of 33 articles covering 26,000 patients, low cholesterol due to drug intervention, conducted over a 5 year period, produced 70% higher cancer mortality. Number one was colon cancer. “…we determined that a 7% reduction in cholesterol resulted in a 70% increase in cancer risk.” [66]
A 7% reduction in cholesterol resulted in a
70% increase in cancer risk.
2016
Statins deplete your body of coenzyme Q10 (CoQ10), which is used for energy production by every cell in your body, and is therefore vital for good health, high-energy levels, longevity, and general quality of life. It is also essential for good heart function! The depletion of CoQ10 caused by the drug, is one reason why statins can increase your risk of acute heart failure. [67]
2018
A study from Australia has linked use of cholesterol-lowering statin drugs, with a significantly increased risk of “Idiopathic Inflammatory Myositis”, a serious muscle disease that can lead to permanent disability and death. “…there was a statistically significant, 79% increased likelihood of statin exposure in patients with idiopathic inflammatory myositis, compared with controls.” [68]
2018
There is now a strong link between use of statins and the increased risk of dementia and Alzheimer’s disease. The association is so strong that the researchers concluded that cholesterol may be considered as a “potential protective factor against cognitive decline.”[69] Higher cholesterol levels are associated with better cognitive function in people over 65 years. [70],[71],[72]
“Statins also inhibit the synthesis of vitamin K2, which can make your heart health worse instead of better and reduce ketone production. Ketones are crucial nutrients to feed your mitochondria and are important regulators of metabolic health and longevity” [73]
2019
The Mayo Clinic web site lists [74] the following conditions which increase the side effects of statins;
“Muscle pain and damage, severe muscle pain, liver damage, kidney failure and death, type 2 diabetes and Neurological side effects including memory loss or confusion. …some people may be at a greater risk than are others. Risk factors include:
- Taking multiple medications to lower your cholesterol
- Being female
- Having a smaller body frame
- Being age 80 or older
- Having kidney or liver disease
- Drinking too much alcohol”
- Having certain conditions such as hypothyroidism or neuromuscular disorders including amyotrophic lateral sclerosis (ALS)
[Hypothyroidism, Neuromuscular disorders and ALS are all related to mercury poisoning. Mercury form just one amalgam filling will cause a 60% reduction in kidney filtration. Fluoride in the drinking water is another major cause of Hypothyroidism.]
As well they list the drugs which interact badly with statins. It is worth a read if you are taking these.
Side effects of statins are reported by many diverse researchers;
- Type 2 Diabetes; [75],[76],[77],[78]
- Cancer [79],[80],[81]
- Cancer of Kidney [82],[83]
- Cancer of Prostate [84]
- Cancer of Thyroid [85]
- Cancer of Breast [86]
- Endocrine Disruption [87],[88],[89],[90],[91]
- Liver damage [92],[93],[94]
- Neurotoxic Damage [95],[96],[97],[98],[99],[100],[101],[102]
- Muscle Toxicity [103],[104],[105],[106],
- Mitochondrial Function [107],[108]
- Selenium Deficiency [109]
- Cardiotoxic (believe it or not) [110],[111],[112],[113],[114],[115]
- Teratogenic [116],[117],[118],[119],[120],[121],[122]
The UK National Health Service Website, [123] officially confirms that these side effects are known. The NHS is the group that pays for the majority of medical and dental treatments in Great Britain. Britain’s health regulator lists the following as side effects of statin use;
- Nosebleeds,
- sore throat,
- a runny or blocked nose (non-allergic rhinitis),
- headache,
- feeling sick,
- problems with the digestive system such as constipation, diarrhoea, indigestion or flatulence,
- muscle and joint pain,
- increased blood sugar level (hyperglycaemia), an increased risk of diabetes,
- being sick,
- loss of appetite or weight gain,
- difficulty sleeping (insomnia) or having nightmares,
- dizziness,
- loss of sensation or tingling in the nerve endings of the hands and feet (peripheral neuropathy),
- memory problems,
- blurred vision,
- ringing in the ears,
- inflammation of the liver (hepatitis),
- inflammation of the pancreas (pancreatitis), which can cause stomach pain,
- skin problems, such as acne or an itchy red rash,
- feeling unusually tired or physically weak,
- visual disturbances,
- bleeding or bruising easily,
- yellowing of the skin and whites of the eyes (jaundice)
Diabetes is one of the risk factors for heart attacks. Statins influence the development of diabetes! Does that mean that statins increase the risk of heart attack? Yes! I wonder how many cardiologists are aware of this research?
It is also worth noting that cholesterol levels are affected by stress levels as well as the other way around. In his book ‘It’s All In Your Head’, Dr Huggins describes the case of a woman who went to her GP to have a blood check, including cholesterol levels. As she was leaving the surgery, she had a car accident when reversing out of the parking lot. She went back into the doctor’s surgery and the doctor had a great idea to check her cholesterol levels again. When the results came back the cholesterol was substantially higher after the accident, which was only about ten minutes after the first blood was taken.
This is a normal response of the body in stress. When the stress is acute, cholesterol levels increase, and when the stress levels reduce, so too will cholesterol levels. When the mind and/or body is in a state of chronic stress, there is permanently elevated level of cholesterol. As Hans Selye [124],[125],[126],[127] demonstrated in the 1960’s, the bodies reaction to stress is always the same initially. As the stress continues and the parasympathetic nervous system can no longer bring us back to balance, this part tends to not work as well. It’s like the brake pads wearing out and the heavy foot remains on the accelerator. The Sympathetic (fight flight) part of the autonomic nervous system, then runs rampant and the mind/body eventually starts to break down according to its weakest part. Initially though we all have a similar physiological reaction, which Selye termed the ‘General Adaptation Syndrome’.
Lowering the cholesterol produces a reduction in the amount of serotonin floating around in your body, which makes you more depressed and uptight and ‘stressed’. Stress will increase cholesterol. Then you’ll take more and more Statins to bring down the cholesterol, which is a side effect of taking Statins. What a fantastic business model!
I have spoken to many cardiologists and GPs who were horrified by this information and clung to the need for lower and lower cholesterol levels. They cannot acknowledge the published research and push as hard for statins as they do for vaccinations – oops vacations in the Bahamas. Take some time and do your own research – it’s worth being armed with knowledge, when confronted by these medical attitudes.
The good news is that when amalgam fillings are removed and the body burden of mercury is reduced, the cholesterol levels will return to a normal level. [128]
If you are on cholesterol lowering drugs already, and you decide to remove the amalgam fillings, it is critical to have a doctor monitor your cholesterol levels closely. If removing amalgam reduces cholesterol levels even more, you might drop to a critical point where you do not have enough. In other words, you will be overdosing on your current medication and will need to reduce the dose. It is not uncommon for cholesterols to be as low as 2 – this is lethal.
This approach to cholesterol could represent a loss of billions of dollars for the drug companies.
Diet and Cholesterol
Some good news is that butter does NOT increase your cholesterol levels. It is far better to eat butter (especially organic) than any amount of the poison called margarine. According to the Scientific Report of the 2015 Dietary Guidelines Advisory Committee;
“…available evidence shows no appreciable relationship between consumption of dietary cholesterol and serum cholesterol…Cholesterol is not a nutrient of concern for overconsumption.” [129]
At long last there is some light! This has been known for so many years and now we have a government report acknowledging it. Butter and eggs are healthy and will not increase your cholesterol levels! Be aware also that most other pollutants such as herbicides and fungicides are fat soluble, which is why it is important to buy organic butter, as it should have fewer nasties in it. (The same applies for olive oil – you are better to get the organic versions)
Cut your sugar (do not replace it with Aspartame) – try replacing it with organic real honey. Try fermented drinks like kombutcha instead of alcohol. Obesity is a greater risk factor for cholesterol, than the amount you eat. So is sugar, alcohol and believe it or not, caffeine, which “contributed significantly to an increase in total cholesterol and LDL-cholesterol” 79
And for all you coffee lovers this report also states;
“higher amounts of coffee or caffeine had no association with risk of atrial fibrillation, but low doses of caffeine … appeared to have a protective association. [130] In addition, coffee consumption of 1 to 5 cups per day was found to be inversely associated with risk of heart failure…” [131] “… the lowest risk was observed for 4 cups per day.” 81
If coffee increases cholesterol levels, but 4 coffees a day has a protective effect on the heart, then what does that say about the association between cholesterol and heart disease? I too scratch my head with the things that we are told. Perhaps the association between mercury and heart disease is more relevant. Hot coffee will dramatically increase the mercury coming off your fillings. This alone will have a very deleterious effect on your heart. Cholesterol levels will also rise from both the increase in mercury and also the effect of the coffee. There is NO winning so long as you have amalgam in your mouth.
It’s also worth knowing that ingestion of salt will not increase your blood pressure. A recent study of more than 8,000 adults, found only a modest relationship between salt intake and systolic (the top number) blood pressure. This study found that the most important modifiable risk factor for high blood pressure, is body mass index – in other words lose weight. [132],[133] Another head scratcher is that one of the main drugs used to reduce blood pressure – the Beta Blockers – have weight gain as a side effect.[134]
I repeat – don’t believe a word I am saying. Read the published science that is referenced here and make up your own mind. Make any changes to your medications, with the assistance of the medical practitioner you are working with. Show them this material so that they also become informed. This information, although official and published and peer reviewed, is extremely controversial because it reduces the sales of statins.
David Getoff “Facts about Cholesterol”
This is a superb presentation of the effects of cholesterol, diet and how to maintain your health.
The sensible way to think about cholesterol.
Many more of his videos on Youtube.
Calcium Metabolism
Mercury depletes calcium levels in your body, which will have profound effects on everything that needs a bit of calcium. This includes heart function, blood pressure, muscle function, bone strength and a massive range of enzyme functions. [135],[136]
Calcium plays a role in strengthening bones and teeth, sperm motility, blood clotting and transmission of nervous system messages as well as proper functioning of the immune system.
“…mercury directly acts on the bone cells and influences calcium homeostasis” [137]
Calcium is also essential for growth of your newborn baby, and vast quantities of calcium are transferred from mother to child in the breast milk.
It is worth noting that calcium is also displaced by fluoride from drinking water (or other sources like dentistry). This is why there is an increase heart attack rate when fluoride levels in water are accidentally set too high!
Blood
Dental amalgam is the major source of mercury found in the blood. [138] Mercury will remain in the blood for only about 12 hours. After that it is locked into the cells.
The ways that mercury can affect the blood itself, may not be immediately recognized by standard pathology tests. In fact, what is regarded as a ‘normal’ parameter in a blood test, will be influenced by the percentage of the population that has amalgam fillings. If we all have the same disease, then that is regarded as normal. In this sense the concept of ‘normal’ is merely a statistical aberration, derived from the number of people having the same range of symptoms. A medical doctor once laughed at me, as he explained that it is normal to have mercury show up in the blood, because most people do. He had no interest from where any of this mercury came, or what it potentially was doing to his patients. It also made no difference to him that there should not be any mercury showing in the blood, unless you have been exposed to it. I politely left his office.
For example, in populations where amalgam is used, the ‘normal range’ of white cell counts varies dramatically from country to country. In Australia a white cell count is normal, in a range of 3,000 to 11,000. In France the normal range is 4,000 to 7,000. A non-amalgam population displays a much narrower band as the normal. This is usually between 5,000 and 6,000 …. What is regarded as normal in Australia, would be of serious concern if the French or non-amalgam normal were used. [139]
By now you will have noticed the large number of quotes that I use especially from some of the best researchers in the field. Many times, they say it much better than I can. One of these is the late Dr Hal Huggins;
“If mercury vapor remains in the blood stream for more than a few seconds, it may be methylated—as methyl mercury it could pass through the blood brain barrier (BBB), after which it can be oxidized into the ionic form that damages brain tissue. Glial cells in the brain have the highest affinity for absorption and storage of mercury of any cells in the body.” [140]
From the lungs, mercury vapor can be transported into the blood stream, where it may react with cells in the blood. Mercury vapor has been documented to suppress the activity of polymorphonuclear leukocytes.[141] (A polymorphonuclear leukocyte is a type of white blood cell that has granules with enzymes that are released during infections, allergic reactions, and asthma.)
Effects on blood are easily demonstrable. Take a series of blood profiles before and then 1, 2 and 4 months after amalgam removal and watch the picture change. You will find that wherever you start from, your white cell count will move toward 5,000 – 6,000.
When mercury vapor enters the red blood cells, it may be oxidized to form ionic mercury, which can immediately kill these red blood cells. [142] If the mercury vapor does not immediately kill the cell, it can displace oxygen on the hemoglobin molecule, altering its three-dimensional structure. [143],[144]
It is well known that mercury binds strongly to the sulfhydryl components of the hemoglobin in red blood cells. This means that a mercury atom is bound to a site that would normally be carrying oxygen around your body. The Hemoglobin molecule normally carries two oxygen atoms. If one of these sites is taken by mercury, you will only be able to carry half as much oxygen in your blood. Try breathing through just one nostril for a while. You will soon have a good idea of what chronic fatigue feels like. It is so easy to be so tired. It may also mean that there is less oxygen to the extremities, so that feet and hands feel cold and painful. This may be diagnosed as Raynaud’s Syndrome, which affects up to 35% of people.
The oxygen saturation of the blood can be measured in many ways – one of those is to measure the amount of oxygen attached to the hemoglobin. It is a measure of ‘oxyhemoglobin’. Dr Huggins states;
“Oxyhemoglobin expected levels are from 65 to 75% saturation. On our chronically fatigued patients the average saturation level was 40.3%” 134
Minute amounts of mercury (at levels as low as 1ppb) will also make red blood cells explode. Yep, they just die. That’s even less oxygen to exist on. And the mercury stays intact to continue to devastate another red cell! 268,[145],[146], At these low levels it also does severe damage to blood vessels. [147],[148],[149]
“In red blood cells, we see the formation of intracellular bacterial forms…….they will seemingly connect and form a mycelial mat. This is exacerbated by mercury. It can also be induced by beryllium and tin. It is often found in cancer patients, and we have also seen it in certain arthritic patients.”
“Finally, there is a form referred to as a medusae or medusal head. It is a microbial form which has mycelial and fungal-like qualities. It is frequently seen in AIDS patients, and occasionally may be found in cancer patients. We have induced the medusal form by mercury exposure for about one hour in the blood of a patient who has no diagnosed disease and appears completely healthy.”[150]
Mercury also causes damage to, and weakening of, the blood vessel walls. This results in damage or death of the affected tissues. The medical term is ‘microangiopathy’. We all know what happens when blood vessels become weak and rupture. We have all heard of strokes and aortic aneurisms. Some of the more common associations are Myocardial infarct (heart attack), Liver damage, Reynaud’s Syndrome & Nerve tissue damage[151]
Mercury also causes oxidation reactions in the blood. This will certainly make you feel sick and chronically fatigued. [152],[153],[154]
Mercury also causes hypercoagulation of blood. [155] ie mercury will cause you to be on blood thinners for the rest of your life after a heart attack.
Cellular Effects
At the cellular level, mercury exposure is associated with alterations in membrane permeability, changes in macromolecular structure due to its affinity for sulfhydryl and thiol groups, and DNA damage.[156],[157],[158] Mercury has also been shown to induce oxidative stress and mitochondrial dysfunction [159] which can result in alterations in calcium homeostasis and increased lipid peroxidation. In addition, mercury will also increase radical oxygen species levels.[160]
Its ability to bind to sulphydryl groups produces two devastating effects. One is that there is an increased production of certain forms of sulphur that are extremely toxic and difficult for the body to eliminate. The other is that it removes the sulphur needed for almost all enzymatic processes as it does by binding to selenium. Hormone, nerve and blood cell functions are also sulphur dependant. There is a strong association with Parkinson’s and Alzheimer’s disease as well as rheumatoid arthritis, autism, lupus and motor neurone disease.[161],[162],[163],[164],[165],[166],[167],[168],[169] The mercury from amalgam could easily disrupt almost all metabolic processes. [170],[171],[172],[173],[174],[175],[176]
References
[1] M.F. Ziff et al, A Persuasive New Look at Heart Disease As It Relates toMercury, Bio- Probe, Inc., ISBN 0-941011-08-9; & J. of American College of Cardiology V33,#6, pp1578‑1583, 1999
[2] A Kistner, “Quecksilbervergiftung durch Amalgam: Diagnose und Therapie” ZWR, 1995,104(5):412-417; & Mass C, Bruck W. “Study on the significance of mercury accumulation in the brain from dental amalgam fillings through direct mouth-nose- brain transport”, Zentralbl Hyg Umweltmed 1996; 198(3): 275-91.
[3] S.Ziff and M.Ziff, Infertility and Birth Defects: Is Mercury from Dental Fillings a Hidden Cause?, Bio-Probe, Inc. ISBN: 0-941011-03-8.1987
[4] E.Lutz et al, “Concentrations of mercury in brain and kidney of fetuses and infants”, Journal of Trace Elements in Medicine and Biology, 1996,10:61-67; & G.Drasch et al, “Mercury Burden of Human Fetal and Infant Tissues”, Eur J Pediatr 153:607-610,1994;
[5] M.C. Newland et al,”Behavioral consequences of in utero exposure to mercury vapor in squirrel monkeys”, Toxicology & Applied Pharmacology, 1996, 139: 374-386; & “Prolonged behavioral effects of in utero exposure to methyl mercury or lead”, Toxicol Appl Pharmacol, 1994, 126(1):6-15;
& K.Warfvinge et al, “Mercury distribution in neonatal cortical areas …after exposure to mercury vapor”, Environmental Research, 1994, 67:196-208.
[6] Chang LW, Hartmann HA,”Blood-brain barrier dysfunction in experimental mercury intoxication”. Acta Neuropathol (Berl) 1972;21(3):179-84;
[7] D. Echeverria et al, “Neurobehavioral effects from exposure to dental amalgam: new distinctions between recent exposure and Hg body burden” FASEB J, Aug 1998, 12(11):971-980; & Amalgam and Health, Swedish Council for Planning and Coordination of Research, 1999; p297-307.
[8] Magos L, Clarkson TW, Hudson AR. The effects of dose of elemental mercury and first pass circulation time on organ distribution of inorganic mercury in rats. Biochim Biophys Acta 1989; 991(1):85-9.
[9] Facts about Mercury and Dental Amalgam (with Medical Study References) Bernard Windham, Editor- Chemical Engineer
[10] Hemodynamic and electrophysiological effects of mercury in intact anesthetized rabbits and in isolated perfused hearts. Rhee HM, Choi BH Exp Mol Pathol 1989 Jun;50(3):281-90
[11] Hussain S, Rodgers DA, Duhart HM, Ali SF. Mercuric chloride-induced reactive oxygen species and its effect on antioxidant enzymes in different regions of rat brain. Journal of Environmental Science and Health—Part B. 1997;32(3):395–409.
[12] Brawer JR, McCarthy GF, Gornitsky M, Frankel D, Mehindate K, Schipper HM. Mercuric chloride induces a stress response in cultured astrocytes characterized by mitochondrial uptake of iron. NeuroToxicology. 1998;19(6):767–776.
[13] Königsberg M, López-Díazguerrero NE, Bucio L, Gutiérrez-Ruiz MC. Uncoupling effect of mercuric chloride on mitochondria isolated from an hepatic cell line. Journal of Applied Toxicology. 2001;21(4):323–329.
[14] Massaroni L, Oliveira EM, Stefanon I, Vassallo DV. Effects of mercury on the mechanical and electrical activity of the Langendorff-perfused rat heart. Brazilian Journal of Medical and Biological Research. 1992;25(8):861–864. 99. Su JY, Chen WJ. The effects of methylmercury on isolated cardiac tissues. American Journal of Pathology. 1979;95(3):753–764
[15] The relationship between mercury from dental amalgam and the cardiovascular system. Siblerud RL Sci Total Environ 1990 Dec 1;99(1-2):23-35
[16] Cardiovascular homeostasis in rats chronically exposed to mercuric chloride. Carmignani M, Boscolo P Arch Toxicol Suppl 1984;7:383-8
[17] Mechanisms in cardiovascular regulation following chronic exposure of male rats to inorganic mercury. Carmignani M, Finelli VN, Boscolo P Toxicol Appl Pharmacol 1983 Jul;69(3):442-50
[18] Marked Elevation of Myocardial Trace Elements in Idiopathic Dilated Cardiomyopathy Compared With Secondary Dysfunction Frustaci, A., Magnavita, N., Chimenti, C., Caldarulo, M., Sabbioni, E., Pietra, R., Cellini, C., Possati, G.F. and Maseri, A. Journal of the American College of Cardiology Vol. 33, No. 6, 1999, pp. 1578-1583
[19] Haffner HT, Erdelkamp J, Goller E, Schweinsberg F, Schmidt V. Morphological and toxicological findings after intravenous injection of metallic mercury. Dtsch Med Wochenschr. 1991;116(36):1342–1346.
[20] Frustaci A, Magnavita N, Chimenti C, Caldarulo M, Sabbioni E, Pietra R, et al. Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. J Am Coll Cardiol. 1999;33(6):1578–1583.
[21] N.V.Klykov, “Treatment of patients with mycardial infarction”, Vrach.Delo.1979,(12):50-3
[22] Sulhydryl-induced restoration of myocardial contractility after alteration by mercury”, Arch. Toxicol. 63(Supp 13) 349-352, 1989
[23] S.Halbach et al, “Thiol chelators and mercury effects on isolated heart muscle”, Plzen.Lek. Sborn, 1990,62(Supp), 39-41, 1990
[24] Effects of mercury on the isolated heart muscle are prevented by DTT and cysteine. Vassallo DV, Moreira CM, Oliveira EM, Bertollo DM, Veloso TC Toxicol Appl Pharmacol 1999 Apr 15;156(2):113-8
[25] Treatment of patients with chronic circulatory insufficiencey” Kardiologila, 1972,12(1):126-31
[26] J.T. Salonen et al, “Intake of mercury from fish and the risk of myocardial infarction and cardiovasculr disease in eastern Finnish men”, Circulation, 1995; 91(3):645-55
[27] Frustaci A, Magnavita N, Chimenti C, Caldarulo M, Sabbioni E, Pietra R, et al. Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. J Am Coll Cardiol. 1999;33(6):1578–1583.
[28] Drescher O, Dewailly E, Diorio C, Ouellet N, Sidi EA, Abdous B, et al. Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults. J Expo Sci Environ Epidemiol. 2014 http://dx.doi.org/10.1038/jes.2013.96.
[29] Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems Bruna Fernandes Azevedo, et al. J Biomed Biotechnol. 2012; 2012: 949048. Published online 2012 Jul 2. doi: 10.1155/2012/949048
[30] Apr 7, 2017 https://www.pharmanord.com/news/selenium-protects-the-heart-muscle
[31] Selenium and cardiovascular disease. Oster O, Prellwitz W. Biol Trace Elem Res. 1990 Feb;24(2):91-103.
[32] Selenium and coronary heart disease: a meta-analysis Gemma Flores-Mateo, Ana Navas-Acien, Roberto Pastor-Barriuso, and Eliseo Guallar . Am J Clin Nutr. 2006 Oct; 84(4): 762–773. doi: 10.1093/ajcn/84.4.762 PMCID: PMC1829306 NIHMSID: NIHMS13284 PMID: 17023702
[33] Selenium and Its Supplementation in Cardiovascular Disease—What do We Know? Carina Benstoem, Andreas Goetzenich, Sandra Kraemer, Sebastian Borosch, William Manzanares, Gil Hardy and Christian Stoppe Nutrients. 2015 May; 7(5): 3094–3118. Published online 2015 Apr 27. doi: 10.3390/nu7053094 PMCID: PMC4446741 PMID: 25923656
[34] International Journal of Cardiology Posted on Apr 10, 2017, 6 a.m.
[35] Guallar E, Sanz-Gallardo MI, Van’T Veer P, et al. Mercury, fish oils, and the risk of myocardial infarction. The New England Journal of Medicine. 2002;347(22):1747–1754.
[36] Fillion M, Mergler D, Sousa Passos CJ, Larribe F, Lemire M, Guimarães JRD. A preliminary study of mercury exposure and blood pressure in the Brazilian Amazon. Environmental Health. 2006;5, article 29
[37] Bastos WR, Gomes JPO, Oliveira RC, et al. Mercury in the environment and riverside population in the Madeira River Basin, Amazon, Brazil. Science of the Total Environment. 2006;368(1):344–351.
[38] Rhee HM, Choi BH. Hemodynamic and electrophysiological effects of mercury in intact anesthetized rabbits and in isolated perfused hearts. Experimental and Molecular Pathology. 1989;50(3):281–290.
[39] Yoshizawa K, Rimm EB, Morris JS, et al. Mercury and the risk of coronary heart disease in men. The New England Journal of Medicine. 2002;347(22):1755–1760.
[40] Houston MC. The role of mercury and cadmium heavy metals in vascular disease, hypertension, coronary heart disease, and myocardial infarction. Alternative Therapies in Health and Medicine. 2007;13(2):S128–S133.
[41] Furieri LB, Fioresi M, Junior RFR, et al. Exposure to low mercury concentration in vivoimpairs myocardial contractile function. Toxicology and Applied Pharmacology. 2011;255(2):193–199.
[42] Furieri LB, Galán M, Avendaño MS, et al. Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species. British Journal of Pharmacology. 2011;162(8):1819–1831.
[43] The chamber exposure of laboratory rats to metal oxides originating from metal producing industry. Kovacikova Z, Chorvatovicova D Physiol Res 1997;46(1):41-5
[44] Mercury effects on the contractile activity of isolated heart muscle. Oliveira EM, Vassallo DV, Sarkis JJ, Mill JG Toxicol Appl Pharmacol 1994 Sep;128(1):86-91
[45] Mercury compounds: lipophilicity and toxic effects on isolated myocardial tissue. Halbach S Arch Toxicol 1990;64(4):315-9
[46] Mercury’s Link To Heart Disease Begins In Blood Vessel Walls May 31, 2007 http://www.sciencedaily.com/releases/2007/05/070531085829.htm
[47] Demasi M Br J Of Sports Med 2018 ;0:1-5 doi:10.1136/bjsports-2017-098497
[48] Science Daily 5 Nov 2018 American Heart Foundation https://www.sciencedaily.com/releases/2018/11/181105081733.htm
[49] Heavy metal as risk factor of cardiovascular disease-an analysis of blood lead and urinary mercury Kim DS, Lee EH, Yu SD, Cha JH, Ahn SC J Prev Med Pub Health (2005 Nov) 38(4):401-7
[50] Toxic Effects of Mercury on the Cardiovascular and Central Nervous Systems Bruna Fernandes Azevedo, et al. J Biomed Biotechnol. 2012; 2012: 949048. Published online 2012 Jul 2. doi: 10.1155/2012/949048
[51] Salonen JT, Seppanen K, Nyyssonen K, et al. Intake of mercury from fish, lipid peroxidation, and the risk of myocardial infarction and coronary, cardiovascular, and any death in Eastern Finnish men. Circulation. 1995;91(3):645–655.
[52] Virtanen JK, Voutilainen S, Rissanen TH, et al. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in Eastern Finland. Arteriosclerosis, Thrombosis, and Vascular Biology. 2005;25(1):228–233.
[53] Hulthe J, Fagerberg B. Circulating oxidized LDL is associated with subclinical atherosclerosis development and inflammatory cytokines (AIR study) Arteriosclerosis, Thrombosis, and Vascular Biology. 2002;22(7):1162–1167.
[54] Halbach S. Mercury compounds: lipophilicity and toxic effects on isolated myocardial tissue. Archives of Toxicology. 1990;64(4):315–319.
[55] https://www.terfinfo.com/Files/Cholesterol%20News%20Article.pdf
[56] Biochemistry Biophysics Acta, Aug 1992
[57] FEMS Microbiol Letter, May 1995 128 (2): 213-18.
[58] Engelberg, H., “Low Serum Cholesterol and Suicide”, Lancet 339:727-728, March 21, 1992
[59] Psychology Today – May 1995
[60] Archives of Internal Medicine (AMA) Apr 10 1995, Vol 155 No.7 p 695.
[61] Molecular Pharmacology 1979; 15: 739-46
[62] British Medical Journal, May 21 1994
[63] Heron – Proc Nat‟l Academy of Science, 1980
[64] The Lipid Research Clinics Coronary Primary Prevention Trial Results: I. Reduction in Incidence of Coronary Heart Disease”, JAMA 251:359, 1984
[65] British Medical Journal, Aug 1990
[66] Cancer Causes and Control, 2, 253-261, 1991 (a review article)
[67] https://articles.mercola.com/sites/articles/archive/2016/04/20/cholesterol-myths.aspx
[68] Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population Gillian E. Caughey et al JAMA Intern Med. 2018;178(9):1224-1230. doi:10.1001/jamainternmed.2018.2859
[69] Frontiers in Neurology November 12, 2018
[70] J Nutr Health Aging. 2016 Mar;20(3):280-7.
[71] J Int Neuropsychol Soc. 2014 Nov;20(10):961-70.
[72] Int J Neurosci. 2017 Mar;127(3):243-252.
[73] https://wakeup-world.com/2018/11/29/statin-use-linked-to-dementia/?fbclid=IwAR24Nf45bmGZo9FkOLCOaJ7ZtVLvZ1uDqUayBODxfhkC32eeulsT9GBz7LM
[74] https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
[75] Endocr J. 2005 Jun ;52(3):369-72. PMID: 16006732
[76] Toxicology. 2016 Feb 17 ;344-346:42-52. Epub 2016 Feb 10. PMID: 26875785
[77] Basic Clin Pharmacol Toxicol. 2016 Aug 24. Epub 2016 Aug 24. PMID: 27553485
[78] Diabetologia. 2015 May ;58(5):1109-17. Epub 2015 Mar 10. PMID: 25754552
[79] J Am Coll Cardiol. 2007 Jul 31 ;50(5):409-18. Epub 2007 Jul 16. PMID: 17662392
[80] Heart Lung Circ. 2009 Oct;18(5):343-6. Epub 2009 Jul 7. PMID: 19586799
[81] CMAJ. 2007 Feb 27 ;176(5):649-54. PMID: 17325332
[82] Expert Opin Drug Saf. 2012 Jul ;11(4):543-9. Epub 2012 Apr 16. PMID: 22502740
Colorectal
[83] Expert Opin Drug Saf. 2012 Jul ;11(4):543-9. Epub 2012 Apr 16. PMID: 22502740
[84] Prostate. 2011 Dec ;71(16):1818-24. Epub 2011 Apr 7. PMID: 21480313
[85] Clin Endocrinol (Oxf). 2014 Jul 30. Epub 2014 Jul 30. PMID: 25074346
[86] Cancer Epidemiol Biomarkers Prev. 2013 Jul 5. Epub 2013 Jul 5. PMID: 23833125
[87] J Biol Chem. 2004 Sep 10 ;279(37):38353-9. Epub 2004 Jul 7. PMID
[88] J Steroid Biochem Mol Biol. 1991 Apr ;38(4):465-8. PMID: 2031860
[89] Exp Clin Endocrinol. 1990 Sep ;96(1):15-24. PMID: 2279522
[90] J Atheroscler Thromb. 2006 Jun ;13(3):123-9. PMID: 16835466
[91] Clin Ther. 1990 Sep-Oct;12(5):410-20. PMID: 2268863
[92] QJM. 2011 Sep 14. Epub 2011 Sep 14.
[93] Minerva Gastroenterol Dietol. 1992 Jan-Mar;38(1):41-4.
[94] Semin Liver Dis. 2009 Nov ;29(4):412-22. Epub 2009 Oct 13.
[95] Neuro Endocrinol Lett. 2011 Sep 3 ;32(5):688-690. Epub 2011 Sep 3.
[96] Neurology. 2002 May 14 ;58(9):1333-7.
[97] J Epidemiol Community Health. 2004 Dec ;58(12):1047-51.
[98] Am J Med. 2004 Dec 1 ;117(11):823-9.
[99] Neth J Med. 2006 Oct ;64(9):334-8.
[100] J Diabetes. 2012 Nov 1. Epub 2012 Nov 1.
[101] Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9.
[102] Pharmacotherapy. 2006 Aug ;26(8):1190-2.
[103] Br J Clin Pharmacol. 2004 Apr ;57(4):525-8.
[104] Clin Pharmacol Ther. 2006 Jun ;79(6):532-9.
[105] Curr Med Res Opin. 2012 Jun 11. Epub 2012 Jun 11.
[106] Br J Clin Pharmacol. 1996 Sep ;42(3):333-7.
[107] Biochem Biophys Res Commun. 2005 Apr 15 ;329(3):1067-75.
[108] J Atheroscler Thromb. 2009;16(6):870-7. Epub 2009 Dec 22.
[109] Lancet. 2004 Mar 13;363(9412):892-4.
[110] Am J Cardiol. 2004 Nov 15 ;94(10):1306-10.
[111] Proc Natl Acad Sci U S A. 1990 Nov;87(22):8931-4.
[112] Diabetes Care. 2012 Aug 8. Epub 2012 Aug 8.
[113] Clin Drug Investig. 2015 Dec 30. Epub 2015 Dec 30.
[114] Biochim Biophys Acta. 1994 Jul 6 ;1200(2):100-8.
[115] Pharmacology. 2008 ;82(1):74-82. Epub 2008 May 27.
[116] Reprod Biol Endocrinol. 2014 Jul 12 ;12(1):65. Epub 2014 Jul 12.
[117] Neurotoxicol Teratol. 1995 Jan-Feb;17(1):31-9.
[118] N Engl J Med. 2004 Apr 8 ;350(15):1579-82.
[119] N Engl J Med. 2005 Jun 30 ;352(26):2759.
[120] Drug Metab Rev. 2011 Feb ;43(1):69-90.
[121] J Biol Chem. 2003 Oct 31 ;278(44):42936-41. Epub 2003 Aug 14.
[122] Birth Defects Res B Dev Reprod Toxicol. 2011 Oct 17. Epub 2011 Oct 17.
[123] https://www.nhs.uk/conditions/statins/side-effects/
[124] Hans selye and the stress response: from “the first mediator” to the identification of the hypothalamic corticotropin-releasing factor. Tachè y ideggyogy sz (2014 mar 30) 67(3-4):95-8
[125] Naming and classification of steroids and human stress ulcers. Articles of historic significance published by Hans Selye 70 years ago. Szabó S, Gyires K Orv Hetil (2015 Aug 30) 156(35)
[126] STRESS, CANCER, AND THE MIND. Selye H Non-serial; Cancer, Stress, and Death. Tache J, Selye H, Day SB, ed. New York, Plenum Medical Book Company., 233 pp., 1979.: 1979
[127] CORRELATING STRESS AND CANCER Selye H Am J Proctol (1979) 30(4):18-20,25-28 1979
[128] Observations from the Metabolic Fringe HAL A. HUGGINS, D.D.S.
[129] Scientific Report of the 2015 Dietary Guidelines Advisory Committee Advisory Report to the Secretary of Health and Human Services and the Secretary of Agriculture https://health.gov/dietaryguidelines/2015-scientific-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf
[130] Salas-Salvadó J, Fernández-Ballart J, Ros E, Martínez-González MA, Fitó M, Estruch R, et al. Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: oneyear results of the PREDIMED randomized trial. Arch Intern Med. 2008;168(22):2449-58.
[131] Salas-Salvadó J, Bulló M, Babio N, MartínezGonzález M, Ibarrola-Jurado N, Basora J, et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care. 2011;34(1):14-9.
[132] Scientific Report of the 2015 Dietary Guidelines Advisory Committee
[133] https://health.clevelandclinic.org/your-diet-and-heart-disease-rethinking-butter-beef-and-bacon/
[134] https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/expert-answers/beta-blockers/faq-20058385
[135] K.Schirrmacher,1998, “Effects of lead, mercury, and methyl mercury on gap junctions and [Ca2+]i in bone cells”, Calcif Tissue Int 1998 Aug;63(2):134‑9.
[136] A.F.Goldberg et al, “Effect of Amalgam restorations on whole body potassium and bone mineral content in older men”,Gen Dent, 1996, 44(3): 246-8
[137] Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism.
Suzuki N J Bone Miner Metab. 2004;22(5):439-46.
[138] Nur Ozdabak H Karaoglanoglu S Akgul N Polat F Seven N The effects of amalgam restorations on plasma mercury levels and total antioxidant activity. Arch Oral Biol (2008 Dec) 53(12):1101-6
[139] Observations from the Metabolic Fringe HAL A. HUGGINS, D.D.S.
[140] H Huggins Explore The Journal of Science and Healing Volume 3, Issue 2, Pages 110-117 (March 2007)
[141] Cantoni O, Costa M. Correlations of DNA strand breaks and their repair with cell survival, following acute exposure to mercury and X-rays. Mol Pharmacol. 1983;24:84–89
[142] Magos L. Mercury-blood interaction and mercury uptake by the brain after vapor exposure. Environ Res. 1967;1:323–327
[143] Riggs AF. Sulfhydrl groups and the interaction between the hemes and hemoglobin. J Gen Physiol. 1952;36:1–16
[144] Stortebecker, P. The Lancet, May 27, 1989
[145] P.Kuhnert et al, “Comparison of Mercury levels in maternal blood fetal cord blood and placental tissue”. Am. J. Obstet and Gynecol.,139:209‑212., 1981
[146] J.Abraham,C.Svare, et al. “The effects of dental amalgam restorations on Blood Mercury levels”. J. Dent.Res. 1984; 63(1):71‑73.
[147] E.M.Oliveira et al, “Mercury effects on the contractile activity of the heart muscle”, Toxicol Appl Pharmacol, 1:86-91,1994;
[148] T.Kishimoto et al, “Methylmercury injury of Cultured Human Vascular EndothelialCells”, Journal of Trace Elements in Experimental Medicine, 6(4): 155-163, 1993.
[149] PatrickStörtebecker,Associate Professor of Neurology, Karolinska Institute, Stockholm. Mercury Poisoning from Dental amalgam-A Hazard to the Human Brains, ISBN: 0-941011001-1
[150] Dr Walter J Clifford MS, RM(AAM), BLD, FIAOMT Proceedings of the First World Congress on Cancer Sydney 1994
[151] Stortebecker, P. Mercury poisoning from dental amalgam through a direct nose-brain transport. The Lancet, May 27, 1989
[152] Pizzichini M Fonzi M Sugherini L Fonzi L Comporti M Gasparoni A Pompella A Release of mercury from dental amalgam and its influence on salivary antioxidant activity. Bull Group Int Rech Sci Stomatol Odontol (2000 May-Dec) 42(2-3):94-100
[153] Pizzichini M Fonzi M Gasparoni A Mencarelli M Rocchi G Kaitsas V Fonzi L Influence of amalgam fillings on Hg levels and total antioxidant activity in plasma of healthy donors. Bull Group Int Rech Sci Stomatol Odontol (2001 May-Sep) 43(2):62-7
[154] Lindh U Carlmark B Gronquist SO Lindvall A Metal exposure from amalgam alters the distribution of trace elements in blood cells and plasma. Clin Chem Lab Med (2001 Feb) 39(2):134-42
[155] [Effects of chronic mercury poisoning on blood coagulation and fibrinolysis systems] Song YG. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Dec;23(6):405-7.
[156] Naganuma A, Furuchi T, Miura N, Hwang GW, Kuge S. Investigation of intracellular factors involved in methylmercury toxicity. Tohoku J Exp Med. 2002;196(2):65–70.
[157] Wang L, Jia G. Progress in developmental toxicity of methylmercury. Wei Sheng Yan Jiu. 2005;34(5):633–635.
[158] Flora SJ, Mittal M, Mehta A. Heavy metal induced oxidative stress & its possible reversal by chelation therapy. Indian J Med Res. 2008;128(4):501–523.
[159] Lund BO, Miller DM, Woods JS. Studies on Hg(II)-induced H2O2 formation and oxidative stress in vivo and in vitro in rat kidney mitochondria. Biochem Pharmacol. 1993;45(10):2017–2024
[160] Peraza MA, Ayala-Fierro F, Barber DS, Casarez E, Rael LT. Effects of micronutrients on metal toxicity. Environ Health Perspect. 1998;106(Suppl 1):203–216.
[161] M.T.Heafield et al, “Plasma cysteine and sulphate levels in patients with Motor neurone disease, Parkinson’s Disease, and Alzheimer’s Disease”, Neurosci Lett, 1990, 110(1‑2), 216,20
[162] A.Pean et al, “Pathways of cysteine metabolism in MND/ALS”, J neurol Sci, 1994, 124, Suppl:59‑61.
[163] C.M. Tanner et al,“Abnormal Liver Enzyme Metablolism in Parkinson’s”,Neurology, 1991, 41(5): Suppl 2, 89-92
[164] P.Emory et al, “Poor sulphoxidation in patients with rheumatoid arthitis”, Ann Rheum Dis, 1992, 51:3,318-20;
[165] P.E. Emory et al, “Increased Prevalence of poor sulphuoxidation in patients with Rheumatoid Arthritis”, Ann Rheum Dis, 1992, 51(3): 318-20
[166] S.A.McFadden, “Xenobiotic metabolism and adverse environmental response: sulfur-dependent detox pathways”,Toxicology, 1996, 111(1-3):43-65
[167] J.P.Spencer et al, “Cysteine & GSH in PD”, mechinsms involving ROS”, J Neurochem, 1998, 71(5):2112-22
[168] P.Jenner,“Oxidative mechanisms in PD”, Mov Disord, 1998; 13(Supp1):24-34
[169] C.Gordon et al, “Abnormal sulphur oxidation in systemic lupus erythrmatosus(SLE)”, Lancet, 1992,339:8784,25-6;
[170] C.Malmström, M.Hansson,M. Nylander, Conference on Trace Elements in Health and Disease. Stockholm May 25‑1992;
[171] C.Malmstrom, “Amalgam derived mercury in feces”, Journal of Trace Elements in Experimental Medicine, 5, (Abs 122), 1992
[172] A.D.Owen et al, Ann NY Acad Sci, 1996, 786:217-33; & JJ Heales et al, Neurochem Res, 1996, 21(1):35-39
[173] T.W.Clarkson et al, “Billiary secretion of glutathione‑metal complexes”, Fundam Appl Toxicol,1985,5(5):816‑31
[174] D.Quig, Doctors Data Lab,”Cysteine metabolism and metal toxicity”, Altern Med Rev, 1998;3:4, p262‑270
[175] D.Jay, “Glutathione inhibits SOD activity of Hg”, Arch Inst cardiol Mex, 1998,68(6):457-61
[176] Pinto OF et al, J Intl Acad Prev Med, Vol 3, No.2, 1976; & Y.Kinjo et al, “Cancer mortality in patients exposed to methylmercury through fish diet”, J Epidemiol, 1996, 6(3):134-8..